Katalytische Friedel-Crafts-Acylierung von Aromaten

Biocatalytic Friedel–Crafts Acylation and Fries Reaction

The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to...

Friedel-Crafts alkylation of Phenol using Ionic Liquid as Catalyst

Deciphering DNA-based asymmetric catalysis through intramolecular Friedel-Crafts alkylations.

We describe asymmetric intramolecular Friedel-Crafts alkylations with a DNA-based hybrid catalyst and propose a plausible binding model. This study shows promise for studying relationships between the helical chirality of DNA and enantioselectivity of the chemical reaction.

Organocatalytic vinyl and Friedel-Crafts alkylations with trifluoroborate salts.

Over the last 8 years, our laboratory has developed the concept of iminium catalysis, a mode of LUMO-lowering activation that has enabled the invention of a large number of enantioselective organocatalytic transformations including Diels-Alder cycloadditions, Friedel-Crafts alkylations, Mukaiyama-Michael additions, hydrogenations, and heteroconjugate additions.1 Central to the utility of this t...

Friedel–Crafts acylation of 2-methoxynaphthalene over zeolite catalysts

The Friedel–Crafts acylation of 2-methoxynaphthalene was carried out in the liquid-phase batch conditions using Hmordenite, H-beta and H-Y zeolite as catalysts. All the catalysts showed 35–40% conversion in the temperature range of 100–150◦C. 1-Acyl-2-methoxynaphthalene was formed as the primary product. When acetyl chloride was used as the acylating agent, a higher yield of 6-acyl-2-methoxynap...